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KMID : 0043319960190050411
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Archives of Pharmacal Research
1996 Volume.19 No. 5 p.411 ~ p.415
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Synthesis and Biological Activity of C-3 Pyridinylethene-substituted Cephalosporins
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Ko Sung-Bo
Lee Yong-Sup
Lee Jae-Yeol
Ham Won-Hun
Park Ho-Koon
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Abstract
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A series of aminothiazolylcephalosporin derivatives (1a-1c) having pyridinylethenyl group at C-3 position was prepared starting from phosphonium salt 3 and 2-, 3- or 4-pyridinecarboxal-dehyde and the antibacterial activity of these compounds was investigated. Among them, 4-pyridinylethenyl derivative was more active than 2- and 3-pyridinylethenyl derivativees against Staphylococcus aureus and Escherichia coli.
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KEYWORD
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Cephalosporins, Antibacterial activity, Pyridinylethenyl, Wittig reaction, Py-ridinecarboxaldehyde
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